Re: changing font in ALV grid possible ?

To be honest, I feel the font change wouldn't even help here. IMHO it'd look better if you just spelled out the week day (or maybe even move it into a separate column?) and lost the comma. At least in English seeing "Friday 1/5/2016" would seem more natural. And, by the way, I hope you are using the user's preferred date format. Because 1/5/2016 in the US is January 5th.

Ask the users what they think about it. Perhaps you're trying to solve a non-existing problem.